News & Publications

May 4th 2015

Endolysin Technology Presents an Antibiotic Alternative with Broad Applicability

Endolysin technology targets unwanted bacteria, including resistant strains.
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January 29th 2015

Micreos invited to speak at the Royal Society of Medicine Spring Summit

Micreos invited to speak at the Royal Society of Medicine Spring Summit 2015 in London, April 18.
Click here for more information about the event

November 13th 2014


Revolutionary New Antibiotic Alternative Could Save the World From Superbug 'Apocalypse'
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November 12th 2014

The Pharmaceutical Journal

New bactericidal enzyme solution could help the fight against MRSA infection.
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November 7th 2014

The Pharma Letter

Micreos' Staphefekt is the world's first bacteria-killing enzyme for human use in MRSA.
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November 6th 2014

Sky Video Coverage

Scientists Develop Alternative To Antibiotics: A new drug based on a naturally-occurring enzyme can fight superbugs which have evolved to resist antibiotics.
Click here to view

November 12th 2014

BNR Health (Business News Radio) interviews Mark Offerhaus

BNR interviews Micreos' CEO Mark Offerhaus on Staphefekt, world's first bacteria-killing enzyme for human use targeting MRSA and Staphylococcus aureus-bacteria causing skin infections.
Click here to listen (Dutch)

November 7th 2014

NPO Radio 1, The Netherlands

Interview with clinical microbiologist Bjorn Herpers and Micreos' CEO Mark Offerhaus on Staphefekt, world's first product targeting MRSA on the skin.
Click here to listen (Dutch)

Press release, November 5, 2014

Dutch biotech Micreos launches first bacteria-killing enzyme for human use against MRSA

 Micreos, a Dutch biotech company, has developed Staphefekt™, a bacteria-killing enzyme specific to Staphylococcus aureus, which is equally effective in killing methicillin-resistant Staphylococcus aureus (MRSA) as methicillin-susceptible Staphylococcus aureus (MSSA).  
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'Antibiotic Alternatives for the New Millennium Conference',  November 5-7, 2014, London, UK

 Specific lysis of Staphylococcus aureus by the endolysin Staphefekt™ SA.100: In vitro studies and human case series - Dr. B.L. Herpers. 
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B.L. Herpers et al., 2014 European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)

Staphefekt™ effectively kills MRSA & MSSA without disturbing normal skin flora

Lysis of S. aureus by Staphefekt SA.100™ is dose dependent, specific and efficient. Staphefekt™ is equally effective in killing both methicillin susceptible and resistant strains, without disturbing the normal skin flora. 
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Allen, H.B. et al. 2014, JAMA Dermatology

The Presence and Impact of Biofilm-Producing Staphylococci in Atopic Dermatitis

Atopic dermatitis lesions are strongly colonized by biofilm producing Staphylococci, which occlude sweat ducts...This would lead to itching, scratching, and the production of a rash. 
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Oh et al. 2013, Genome Res.

The altered landscape of the human skin microbiome in patients with primary immunodeficiences.

S. aureus was most significantly correlated with disease severity. However, it is increasingly clear that microbial pathogens, such as S. aureus, which can asymptomatically colonize human hosts, may only be disease-associated in the context of their microbial communities and host factors.
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Nakamura et al. 2013, Nature

Staphylococcus δ-toxin induces allergic skin disease activating mast cells.

 These studies identify δ-toxin as a potent inducer of mast cell degranulation and suggest a mechanistic link between S. aureus colonization and allergic skin disease. 
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Chiu et al. 2013, Nature

Bacteria activate sensory neurons that modulate pain and inflammation.

 Our data reveal an unsuspected mechanism for pain induction during bacterial infection: Direct activation of sensory neurons (nociceptors) by bacteria is probably a major mechanism leading to pain, especially early in S. aureus infection during active pathogen expansion. 
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Gravitz, L. 2012, Nature Medicine

Turning a new phage.

The idea of using bacteria-fighting viruses as a weapon against hard-to-treat infections is making a surprising comeback. Researchers and companies are now tweaking and deconstructing these bacteria killers in an effort to develop a new arsenal against antibiotic-resistant superbugs. 
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Fluit A.C., Marm van S., et al. 2012, ICAAC

Killing and lysis of S. aureus and other staphylococci by an endolysin.

 Efficient killing of different S. aureus strains is obtained bij using Staphefekt™ SA.100. Staphylococcal species belonging to the normal human commensal flora as well as other species are not affected. 
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Adejuwon A.O., Ajayi A.A. 2010, IJMMS

Antibiotics resistance and susceptibility pattern of a strain of Staphylococus aureus associated with acne.

 Investigation showed the presence of Staphylococcus aureus in pus from acne. 
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Huang J.T., Abrams M., et al. 2009, Pediatrics

Treatment of Staphylococcus aureus Colonization in Atopic Dermatitis Decreases Disease Severity

 S. aureus skin infections in atopic dermatitis are linked to the high rates of S. aureus colonization in the atopic dermatitis population. Treatment of S. aureus colonization in atopic dermatitis decreases disease severity. 
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Leung D.Y.M. 2008, Acta Derm Venereol.

The role of Staphylococcus aureus in atopic eczema.

 Colonization and infection with S. aureus contributes to the severity of atopic eczema, inducing skin inflammation, leading in turn to sustained S. aureus colonization and infection. 
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Gong J.Q., Lin L., et al. 2006, British Journal of Dermatology

Skin colonization by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double-blind multicentre randomized controlled trial.

 A correlation between the severity of the eczema and colonization with S. aureus has been demonstrated, and it has been determined that bacterial colonization is an important factor aggravating skin lesions. 
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